Indicated for:

Edema:

• Indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy.

• HydroDIURIL has also been found useful in edema due to various forms of renal dysfunction such as nephrotic syndrome, acute glomerulonephritis, and chronic renal failure.

Hypertension:

• HydroDIURIL is indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension.

HydroDIURIL is contraindicated in patients with anuria.

Use with caution in severe renal disease. In patients with renal disease, thiazides may precipitate azotemia. 

Thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma.

All patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance: namely, hyponatremia, hypochloremic alkalosis, and hypokalemia.

Thiazides have been shown to increase the urinary excretion of magnesium; this may result in hypomagnesemia.

The possibility of exacerbation or activation of systemic lupus erythematosus has been reported.

All patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance: namely, hyponatremia, hypochloremic alkalosis, and hypokalemia. Serum and urine electrolyte determinations are particularly important when the patient is vomiting excessively or receiving parenteral fluids.

Hydrochlorothiazide, a sulfonamide, can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma.

Lithium should generally not be given with diuretics.

Thiazides may add to or potentiate the action of other antihypertensive drugs.

Potentiation of orthostatic hypotension may occur if HydroDIURIL is used with alcohol, barbiturates, or narcotics.

Dosage adjustment of antidiabetic drugs may be required if used with HydroDIURIL.

Additive effect or potentiation may occur if antidiabetic drugs (oral agents and Insulin) are used with HydroDIURIL.

Absorption of hydrochlorothiazide is impaired in the presence of anionic exchange resins (e.g., Cholestyramine and Colestipol Resins).

Use with Corticosteroids or ACTH Intensifies electrolyte depletion, particularly hypokalemia.

Use with skeletal muscle relaxants, nondepolarizing (e.g., Tubocurarine) Possibly increases responsiveness to the muscle relaxant.

In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics.

Thiazides should be discontinued before carrying out tests for parathyroid function.

Routine use of diuretics during normal pregnancy is inappropriate and exposes mother and fetus to unnecessary hazard. Diuretics do not prevent development toxemia of pregnancy and there is no satisfactory evidence that they are useful in the treatment of toxemia.

Thiazides are excreted in breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother.

GoToSource

• Use in patients under the age of 18. GoToSource

• Reduce urinary calcium in patients with kidney stones. GoToSource

• Prevention of postmenopausal bone loss. GoToSource 

• Congenital nephrogenic diabetes insipidus. GoToSource

Study indicating this is an inappropriate first-line drug for the treatment of hypertension. GoToSource

Endometrial cancer. GoToSource

Sexual dysfunction. GoToSource

Hypokalaemia (low potassium). GoToSource

Hypercalcemia (elevated calcium). GoToSource

Jaundice. GoToSource

Cutaneous drug-induced lupus. GoToSource

Acute secondary angle closure glaucoma. GoToSource

Stevens-johnson syndrome and toxic epidermal necrolysis (severe skin reaction). GoToSource

Pancreatitis (inflammation of the pancreas), sialadenitis (inflammation of salivary glands), agranulocytosis (lowered white blood cell count), leukopenia (low white blood count), thrombocytopenia (low blood platelet count), necrotizing angiitis (inflammation of blood vessel walls) and azotemia. (abnormally high level of nitrogen waste products in the blood). GoToSource

Electrolyte abnormalities, orthostatic hypotension (excessive fall in blood pressure when upright position is assumed), hyperglycemia (high blood sugar) photosensitivity (abnormal skin sensitivity to ultraviolet light), interstitial pneumonitis (severe lung disease), angioedema (swelling in the deep layers of the skin) and aplastic anemia (bone marrow does not make enough new blood cells). GoToSource

Lawsuits filed for stevens-johnson syndrome.