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AccuNeb

Generic Name: Albuterol Sulfate Inhalation Solution
Drug Category: Bronchodilator
Litigation Alert Level: Low
This drug has been approved for use by males and females over the age of 2 years old and under the age of 12 years old for a maximum duration of 12 weeks.

Approved Uses

Indicated for the relief of bronchospasm in patients 2 to 12 years of age with asthma (reversible obstructive airway disease). 

Albuterol sulfate inhalation solution, like other beta-adrenergic agonists, can produce a clinically significant cardiovascular effect in some patients as measured by pulse rate, blood pressure, and/or symptoms.

Albuterol sulfate inhalation solution like all other sympathomimetic amines, should be used with caution in patients with cardiovascular disorders, especially coronary insufficiency, cardiac arrhythmias, and hypertension.

Large doses of intravenous albuterol have been reported to aggravate pre-existing diabetes mellitus and ketoacidosis.

As with other inhaled beta-adrenergic agonists, albuterol sulfate can produce paradoxical bronchospasm, which may be life threatening.

Fatalities have been reported in association with excessive use of inhaled sympathomimetic drugs and with the home use of nebulizers. It is, therefore, essential that the physician instruct the patient in the need for further evaluation, if his/her asthma becomes worse.

Metabolic acidosis has been reported after the use of albuterol sulfate inhalation solution.

Albuterol sulfate should be administered with extreme caution to patients being treated with monoamine oxidase inhibitors or tricyclic antidepressants or within 2 weeks of discontinuation of such agents, since the action of albuterol on the vascular system may be potentiated.

Other short-acting sympathomimetic aerosol bronchodilators or epinephrine should not be used concomitantly with albuterol sulfate.

The ECG changes and/or hypokalemia that may result from the administration of non-potassium sparing diuretics (such as loop or thiazide diuretics) can be acutely worsened by beta-agonists, especially when the dose of the beta-agonist is exceeded.

Beta-receptor blocking agents not only block the pulmonary effect of beta-agonists, such as albuterol sulfate, but may produce severe bronchospasm in asthmatic patients.Therefore, patients with asthma should not normally be treated with beta-blockers.

Albuterol has not been approved for the management of preterm labor. The benefit:risk ratio when albuterol is administered for tocolysis has not been established. Serious adverse reactions, including pulmonary edema, have been reported following administration of albuterol to women in labor.

Because of the potential for tumorigenicity shown for albuterol in some animal studies, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

It is not known whether this drug is excreted in human milk. Because of the potential for tumorigenicity shown for albuterol in some animal studies, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

GoToSource

Off-label Uses

• Improvement of muscle mass and strength in patients with facioscapulohumeral muscular dystrophy. GoToSource

• Relief of symptoms of bronchopulmonary dysplasia in newborns. GoToSource

• To improve response to levodopa and increase skeletal muscle mass in patients with fluctuating parkinson disease. GoToSource

• Use in patients under the age of 2 and over the age of 12. GoToSource 

• Multiple sclerosis. GoToSource

Adverse Events

Paradoxical bronchoconstriction. GoToSource

Tremors. GoToSource

Increased heart rate. GoToSource

Hyperactivity and inattentiveness. GoToSource

Litigation

No major injury lawsuits reported.

The material contained in GoToPills is for informational purposes only and not intended to replace the judgment, evaluation and treatment of physicians, pharmacists and other healthcare providers. GoToPills does not provide medical advice, diagnoses or treatment. Always seek the advice of your physician or other qualified health provider regarding a medical condition or treatment.

 

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Site Last Updated March 28, 2024